ABSTRACT
Objective To compare the differences in plantar kinetics between older male adults and young male adults during walking, and to explore the influences of aging on plantar kinetics. Methods The in-shoe plantar sensory measurement system was used to collect and compare left foot parameters of 13 older men and 14 young men during tandem walk, including contact time, beginning of contact in percentage of roll over process (%ROP), and end of contact in %ROP, peak pressure, instant of peak pressure in %ROP, maximum mean pressure, pressure-time integral, maximum force, instant of maximum force in %ROP, mean force and force-time integral. Results Beside media arch, the contact time on all regions of older men was longer, whereas, the beginning of contact in %ROP on lateral heel, lateral arch was greater, and the end of contact in %ROP on medial heel and 2nd-3rd metatarsal head was smaller compared with young men. The maximum force and mean force on the whole foot region, and the maximum mean pressure and maximum force on 2nd-3rd metatarsal head of older people were significantly lower; the pressure-time integral on the whole foot region, the 4th-5th metatarsal head, the 2nd -5th toes, and the force-time integral on the whole foot region, medial heel, lateral heel and 2nd -5th toes were significantly higher compared with young men. Conclusions During tandem walking, plantar fascia dysfunction might be one of the main reasons for the decline of postural control ability, and the contraction enhancement of flexor digitorum longus and flexor digitorum brevis could compensate for postural stability improvement in older men.
ABSTRACT
Objective To compare the differences in long-term jogging and Tai Chi in terms of neuromuscular latency and time to peak of surface electromyography (EMG) in older males during lateral sudden perturbation. In addition, an effective means to enhance neuromuscular response and muscle contraction efficiency of older males during lateral postural challenges was investigated. Methods Postural reactions of young males, older sedentary male controls (without regular exercises), older male joggers (with long-term jogging practice), and older male Tai Chi participants (with long-term Tai Chi practice) were evoked by means of a sudden unpredictable lateral translation platform. Surface EMG signals of peroneus longus, anterior tibialis, gluteus medius, and erector spinae were collected by an EMG detection and analysis system. Results The latencies of peroneus longus, anterior tibialis, and gluteus medius were delayed in the older sedentary male controls compared with those in young males. The neuromuscular reactions of anterior tibialis and erector spinae in older Tai Chi male participants were faster than those of older sedentary male controls. The contraction speeds of peroneus longus, anterior tibialis, and gluteus medius in young males were higher than those in three older groups during sudden lateral perturbations. Conclusions Long-term Tai Chi practice can enhance the responses of ankle and trunk muscles of older males during lateral postural challenges, but it has little effect on the muscle contraction efficiency of older males.
ABSTRACT
Objectives To investigate the clinical profile and prognosis of hemophagocytic syndrome (HPS). Methods A retrospective study was carried out to analyze the clinical features and laboratory findings in 28 children with HPS. Fisher's exact probability method and Logistic multivariate regression were used to explore the prognostic risk factors.. Results HPS was clinically characterized by prolonged fever (100%), hepatomegaly (64.29%),and other minor features including respiratory symptoms (53.57%), splenomegaly (50%), hydrops of multiple serous cavity (42.86%), lymphadenectasis (32.14%), jaundice (17.85%), skin rash (14.29%), central nervous system involvement (14.29%), and alimentary tract hemorrhage (10.71%). Labo-ratory data showed that 1iver dysfunction, pancytopenia, coagulation abnormalities, disseminated intravascular coagulation, hy-pertriglyceridemia, decreased number of natural killer cells and hyponatremia were prominent. The etiological analysis indicated that infection associated hemophagocytic syndrome was most common (60.71%), in which EB virus associated HPS was pre-dominant, accounting for 64.71%. Significant difference was observed in the difference of albumin,blood urea nitrogen and acti-vated partial thromboplastin time between death and survival cases (P<0.05). The Logistic regression multivariate analysis showed that hypoalbuminemia was an independent prognostic factor. Conclusions There are various underlying diseases and clinical manifestations for HPS. The lower level of serum albumin is an independent prognostic factor. A prompt diagnosis and treatment is very important for HPS prognosis due to the rapid progression and high mortality.
ABSTRACT
Objective To study sodium cantharidinate induced apoptosis of human esophageal carcinoma Eca109 in vitro. Methods The change of human esophageal carcinoma Eca109 treated with sodium cantharidinate were analyzed by MTT and FCM assay. Results Human esophageal carcinoma Eca109 were treated with sodium cantharidinate for 24 h,the cell proliferation was obviously inhibited(P
ABSTRACT
Objective:To study effects of 5 recipes for tonifing and supplementing on apoptosis and splenocytes in mice treated with cyclophosphamide.Methods:Apoptosis and cellular cycles of splenocytes were detected by flowcytometric analysis.Results:Sijunzi Decoction,Liuwei Dihuang Pill,Shengmai Powder,Jingui Shenqi Pill could antagonize the decline of proliferation induced by cyclophosphamide,and Sijunzi Decoction and Liuwei Dihuang Pill could resist the apoptosis of splenocytes caused by cyclophosphamide;and the recipes all could inhibit atrophy of the spleen induced by cyclophosphamide Conclusion:The 5 recipes for tonifying and supplementing all can improve the injury of the spleen induced by cyclopbosphamide in varying degrees,Sijunzi Decoction and Liuwei Dihuang Pill being the best.
ABSTRACT
AIM: To explore the molecular mechanism of Radix Ophioponis against vascular endothelial cell (VEC) apoptosis induced by LPS. METHODS: The apoptosis of human umbilical vascular endothelial cells(HUVEC) was induced by lipopolysaccharide(LPS). The influence of Radix Ophiopogonis on the expression of bcl-2 and intracellular Ca 2+ was detected by flow cytometry and laser confocal microscope. RESULTS: The serum containing Radix Ophiopogonis suppressed the increase in bcl-2 expression and overloading of Ca 2+ induced by LPS in HUVEC.CONCLUSION: The mechanism of Radix Ophiopogonis against HUVEC apotosis may be related with its regulatory effect on bcl-2 expression and remission of Ca 2+ overloading.